![]() The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/beta-catenin signaling. Han P, Li JW, Zhang BM, Lv JC, Li YM, Gu XY, et al. Poison-Exon Inclusion in DHX9 Reduces Its Expression and Sensitizes Ewing Sarcoma Cells to Chemotherapeutic Treatment. Anti-tumor activity of splice-switching oligonucleotides. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Marchesini M, Ogoti Y, Fiorini E, Aktas Samur A, Nezi L, D’Anca M, et al. Alternative splicing: new insights from global analyses. miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells. Rasmussen MH, Lyskjaer I, Jersie-Christensen RR, Tarpgaard LS, Primdal-Bengtson B, Nielsen MM, et al. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Siegel RL, Miller KD, Goding Sauer A, Fedewa SA, Butterly LF, Anderson JC, et al. 5-fluorouracil: mechanisms of action and clinical strategies. DNA repair pathways as targets for cancer therapy. Helleday T, Petermann E, Lundin C, Hodgson B, Sharma RA. ![]() ![]() a personalized approach to clinical decision making. ![]() ESMO Consensus Guidelines for management of patients with colon and rectal cancer. Schmoll HJ, Van Cutsem E, Stein A, Valentini V, Glimelius B, Haustermans K, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Thus, measuring and targeting CACClnc and its associated pathway could yield valuable insight into clinical management and might ameliorate CRC patients’ outcomes.īray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. In addition, expression of exosomal CACClnc in peripheral plasma of CRC patients can effectively predict the chemotherapy effect of patients before treatment. Mechanistically, CACClnc specifically bound to Y-box binding protein 1 (YB1, a splicing factor) and U2AF65 (a subunit of U2AF splicing factor), promoting the interaction between YB1 and U2AF65, and then modulated alternative splicing (AS) of RAD51 mRNA, and consequently altered CRC cell biology. CACClnc promoted CRC resistance to chemotherapy via promoting DNA repair and enhancing homologous recombination in vitro and in vivo. In this study, we identified a novel lncRNA, CACClnc, which was upregulated and associated with chemoresistance and poor prognosis in colorectal cancer (CRC). However, the effect of lncRNA on chemoresistance and RNA alternative splicing remains largely unknown. There's still a chance to experience some of the flavour of last year's festival by having a look at our online exhibition which showcases some of the most interesting interactive sonic art around.Long non-coding RNAs (lncRNAs) play important roles in carcinogenesis. More at Sonic Arts Network | Roedelius | Eliane Radigue | Francois Bayle To finish, Francois Bayle presents his 1972 classic L' Experience Acoustique. Veteran Krautrock pioneer Hans Joachim Roedelius presents a new work, plus laptop supergroup the Lappetites perform the music of Eliane Radigue. More at Sonic Arts Network | CM von Hausswolff | Karkowski | Chion | Russell Haswell bio More at Sonic Arts Network | Christian Zanesi bio | John Wall siteĬonceptual sonics from CM von Hausswolff, avant chamber music group Apartment House play Zbigniew Karkowski's Field for string quartet, classic 1970s musique concrete from Michel Chion, and sonic artist Hecker presents an exclusive performance developed for the us a late night DJ set from Russell Haswell. Plus a late night session from turntablist extraordinaire Philip Jeck. In the first of two programmes, Robert Worby presents music from Zbigniew Karkowski, Michel Chion and John Wall.Įlectroacoustic double bill, featuring GRM member Christian Zanési and a rare performance from the UK's own John Wall. This year offered a rare chance to hear the legendary Acousmonium, an orchestra of over 80 louspeakers created by Group de Recherches Musicales co-founder Francois Bayle, as the Sonic Arts Network brought it to London's Institute of Contemporary Arts. Over three days it was put through its paces by some of the most interesting and cutting edge musicians around. Sonic Arts Network, the ICA and BBC Radio 3
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